Cortical superficial siderosis: detection and clinical significance in cerebral amyloid angiopathy and related conditions (2024)

Charidimou, A., Linn, J., Vernooij, M., Opherk, C., Akoudad, S., Baron, JC., Greenberg, SM., Jager, HR., & Werring, DJ. (2015). Cortical superficial siderosis: detection and clinical significance in cerebral amyloid angiopathy and related conditions. Brain, 138, 2126-2139. https://doi.org/10.1093/brain/awv162

Charidimou, A ; Linn, J ; Vernooij, Meike et al. / Cortical superficial siderosis: detection and clinical significance in cerebral amyloid angiopathy and related conditions. In: Brain. 2015 ; Vol. 138. pp. 2126-2139.

@article{cafb254d8aa3457ba09a5f76802515d9,

title = "Cortical superficial siderosis: detection and clinical significance in cerebral amyloid angiopathy and related conditions",

abstract = "Cortical superficial siderosis (cSS) describes the deposition of blood-breakdown products over the cerebral hemisphere convexities. Often seen in cerebral amyloid angiopathy, cSS is associated with transient focal neurological episodes and increased intracerebral haemorrhage risk. Charidimou et al. review recent advances in the detection of cSS, plus mechanisms and clinical implications.Cortical superficial siderosis (cSS) describes the deposition of blood-breakdown products over the cerebral hemisphere convexities. Often seen in cerebral amyloid angiopathy, cSS is associated with transient focal neurological episodes and increased intracerebral haemorrhage risk. Charidimou et al. review recent advances in the detection of cSS, plus mechanisms and clinical implications.Cortical superficial siderosis describes a distinct pattern of blood-breakdown product deposition limited to cortical sulci over the convexities of the cerebral hemispheres, sparing the brainstem, cerebellum and spinal cord. Although cortical superficial siderosis has many possible causes, it is emerging as a key feature of cerebral amyloid angiopathy, a common and important age-related cerebral small vessel disorder leading to intracerebral haemorrhage and dementia. In cerebral amyloid angiopathy cohorts, cortical superficial siderosis is associated with characteristic clinical symptoms, including transient focal neurological episodes; preliminary data also suggest an association with a high risk of future intracerebral haemorrhage, with potential implications for antithrombotic treatment decisions. Thus, cortical superficial siderosis is of relevance to neurologists working in neurovascular, memory and epilepsy clinics, and neurovascular emergency services, emphasizing the need for appropriate blood-sensitive magnetic resonance sequences to be routinely acquired in these clinical settings. In this review we focus on recent developments in neuroimaging and detection, aetiology, prevalence, pathophysiology and clinical significance of cortical superficial siderosis, with a particular emphasis on cerebral amyloid angiopathy. We also highlight important areas for future investigation and propose standards for evaluating cortical superficial siderosis in research studies.",

author = "A Charidimou and J Linn and Meike Vernooij and C Opherk and Saloua Akoudad and JC Baron and SM Greenberg and HR Jager and DJ Werring",

year = "2015",

doi = "10.1093/brain/awv162",

language = "Undefined/Unknown",

volume = "138",

pages = "2126--2139",

journal = "Brain",

issn = "0006-8950",

publisher = "Oxford University Press",

}

Charidimou, A, Linn, J, Vernooij, M, Opherk, C, Akoudad, S, Baron, JC, Greenberg, SM, Jager, HR & Werring, DJ 2015, 'Cortical superficial siderosis: detection and clinical significance in cerebral amyloid angiopathy and related conditions', Brain, vol. 138, pp. 2126-2139. https://doi.org/10.1093/brain/awv162

Cortical superficial siderosis: detection and clinical significance in cerebral amyloid angiopathy and related conditions. / Charidimou, A; Linn, J; Vernooij, Meike et al.
In: Brain, Vol. 138, 2015, p. 2126-2139.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Cortical superficial siderosis: detection and clinical significance in cerebral amyloid angiopathy and related conditions

AU - Charidimou, A

AU - Linn, J

AU - Vernooij, Meike

AU - Opherk, C

AU - Akoudad, Saloua

AU - Baron, JC

AU - Greenberg, SM

AU - Jager, HR

AU - Werring, DJ

PY - 2015

Y1 - 2015

N2 - Cortical superficial siderosis (cSS) describes the deposition of blood-breakdown products over the cerebral hemisphere convexities. Often seen in cerebral amyloid angiopathy, cSS is associated with transient focal neurological episodes and increased intracerebral haemorrhage risk. Charidimou et al. review recent advances in the detection of cSS, plus mechanisms and clinical implications.Cortical superficial siderosis (cSS) describes the deposition of blood-breakdown products over the cerebral hemisphere convexities. Often seen in cerebral amyloid angiopathy, cSS is associated with transient focal neurological episodes and increased intracerebral haemorrhage risk. Charidimou et al. review recent advances in the detection of cSS, plus mechanisms and clinical implications.Cortical superficial siderosis describes a distinct pattern of blood-breakdown product deposition limited to cortical sulci over the convexities of the cerebral hemispheres, sparing the brainstem, cerebellum and spinal cord. Although cortical superficial siderosis has many possible causes, it is emerging as a key feature of cerebral amyloid angiopathy, a common and important age-related cerebral small vessel disorder leading to intracerebral haemorrhage and dementia. In cerebral amyloid angiopathy cohorts, cortical superficial siderosis is associated with characteristic clinical symptoms, including transient focal neurological episodes; preliminary data also suggest an association with a high risk of future intracerebral haemorrhage, with potential implications for antithrombotic treatment decisions. Thus, cortical superficial siderosis is of relevance to neurologists working in neurovascular, memory and epilepsy clinics, and neurovascular emergency services, emphasizing the need for appropriate blood-sensitive magnetic resonance sequences to be routinely acquired in these clinical settings. In this review we focus on recent developments in neuroimaging and detection, aetiology, prevalence, pathophysiology and clinical significance of cortical superficial siderosis, with a particular emphasis on cerebral amyloid angiopathy. We also highlight important areas for future investigation and propose standards for evaluating cortical superficial siderosis in research studies.

AB - Cortical superficial siderosis (cSS) describes the deposition of blood-breakdown products over the cerebral hemisphere convexities. Often seen in cerebral amyloid angiopathy, cSS is associated with transient focal neurological episodes and increased intracerebral haemorrhage risk. Charidimou et al. review recent advances in the detection of cSS, plus mechanisms and clinical implications.Cortical superficial siderosis (cSS) describes the deposition of blood-breakdown products over the cerebral hemisphere convexities. Often seen in cerebral amyloid angiopathy, cSS is associated with transient focal neurological episodes and increased intracerebral haemorrhage risk. Charidimou et al. review recent advances in the detection of cSS, plus mechanisms and clinical implications.Cortical superficial siderosis describes a distinct pattern of blood-breakdown product deposition limited to cortical sulci over the convexities of the cerebral hemispheres, sparing the brainstem, cerebellum and spinal cord. Although cortical superficial siderosis has many possible causes, it is emerging as a key feature of cerebral amyloid angiopathy, a common and important age-related cerebral small vessel disorder leading to intracerebral haemorrhage and dementia. In cerebral amyloid angiopathy cohorts, cortical superficial siderosis is associated with characteristic clinical symptoms, including transient focal neurological episodes; preliminary data also suggest an association with a high risk of future intracerebral haemorrhage, with potential implications for antithrombotic treatment decisions. Thus, cortical superficial siderosis is of relevance to neurologists working in neurovascular, memory and epilepsy clinics, and neurovascular emergency services, emphasizing the need for appropriate blood-sensitive magnetic resonance sequences to be routinely acquired in these clinical settings. In this review we focus on recent developments in neuroimaging and detection, aetiology, prevalence, pathophysiology and clinical significance of cortical superficial siderosis, with a particular emphasis on cerebral amyloid angiopathy. We also highlight important areas for future investigation and propose standards for evaluating cortical superficial siderosis in research studies.

U2 - 10.1093/brain/awv162

DO - 10.1093/brain/awv162

M3 - Article

SN - 0006-8950

VL - 138

SP - 2126

EP - 2139

JO - Brain

JF - Brain

ER -

Charidimou A, Linn J, Vernooij M, Opherk C, Akoudad S, Baron JC et al. Cortical superficial siderosis: detection and clinical significance in cerebral amyloid angiopathy and related conditions. Brain. 2015;138:2126-2139. doi: 10.1093/brain/awv162